A recurrent pattern of chromosomal aberrations and immunophenotypic appearance defines anal squamous cell carcinomas
نویسندگان
چکیده
منابع مشابه
Comprehensive multiplatform biomarker analysis of 199 anal squamous cell carcinomas.
Anal squamous cell carcinoma (ASCC) is a rare, HPV-associated malignancy typically diagnosed in early stages and definitively treated with chemoradiation. In situations where patients exhibit metastatic or recurrent disease, treatment options are severely limited. In this study, molecular alterations were identified that could be used to aid in therapeutic decisions for patients with metastatic...
متن کاملDistinct nonrandom patterns of chromosomal aberrations in the progression of squamous cell carcinomas of the head and neck.
Fifty-one randomly selected primary squamous cell carcinomas of the head and neck, derived from the larynx (n = 18) and pharynx (oropharynx, n = 18, and hypopharynx, n = 15) were analyzed with centromeric probes for chromosomes 1, 7, 9, 11, 17, and 18 to study numerical aberrations, chromosome imbalances, and aneuploidy by fluorescence in situ hybridization. The tumors were grouped into nonmeta...
متن کاملDistinct Nonrandom Patterns of Chromosomal Aberrations in the Progression of Squamous Cell Carcinomas of the Head and Neck1
Fifty-one randomly selected primary squamous cell carcinomas of the head and neck, derived from the larynx (n = 18) and pharynx (oropharynx, n = 18, and hypopharynx, n = 15) were analyzed with centromeric probes for chromosomes 1, 7, 9, 11, 17, and 18 to study numerical aberrations, chromosome imbalances, and aneuploidy by fluorescence in situ hybridization. The tumors were grouped into nonmeta...
متن کاملMultiple recurrent squamous cell carcinomas and utility of anticytokeratin immunohistochemistry
AE1/AE3: anti-pan cytokeratin 1/3 ART: adjuvant radiation therapy H&E: hematoxylin and eosin IHC: immunohistochemistry SCC: squamous cell carcinoma INTRODUCTION Mohs micrographic surgery remains the gold standard for the treatment of cutaneous squamous cell carcinomas (SCCs) of the head and neck. However, for recurrent or aggressive SCCs, it can be challenging at times to ensure complete margin...
متن کاملChromosomal aberrations identified in culture of squamous carcinomas are confirmed by fluorescence in situ hybridisation.
AIMS Chromosomal aberrations in tumour cells are often not discernable by direct analysis. Although cell culture allows qualitative analysis of the karyotype, potential selection and evolution during growth in vitro may yield misleading data. To determine whether aberrations observed in vitro are representative of the original lesion, chromosomal aberrations found after prolonged growth in vitr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1997
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1997.547